Crystallization: Mastering Seeded Cooling

Moussa Boukerche

Course description

Crystallization plays a pivotal role in the production of high-quality specialty bulk products. This process will influence particle size, purity, and product yield all while needing to be monitored and controlled to meet a product’s specifications. This accredited training course will provide participants with a comprehensive understanding of the vital role of crystallization, focusing on organic compounds like drug substances and intermediates. The course aims to address the common challenges in controlling cooling crystallization processes within industries such as pharmaceuticals, food, fine chemicals, and cosmetics.

By exploring advanced techniques in seeded crystallization, participants will acquire practical knowledge of fundamental principles, phase diagrams, and seeding strategies via real-world case studies. The course objectives include delving into the intricacies of temperature control, and diverse seeding techniques, and highlighting innovative in-situ seedbed formation techniques using high-shear wet mill or sonication.

Additionally, participants will explore scaling up processes, addressing challenges, ensuring safety, and considering environmental factors. By the end of the course, attendees will be well-equipped to navigate the complexities of seeded cooling crystallization processes, applying learned techniques effectively in diverse industrial settings to contribute to the efficient and consistent production of large-scale crystallized products with defined physical properties.

Upon completion of this course, you will be able to:

• Identify and explain the fundamental concepts of crystallization from solution, encompassing principles, phase diagram essentials, and strategies to avoid secondary nucleation.
• Make use of practical insights into seeded crystallization, including effective temperature control, various seeding techniques, and monitoring strategies through real-world case studies.
• Maximize your toolkit with a unique focus on in-situ seedbed formation using a high-shear wet mill or sonication, providing additional strategies for achieving optimal crystallization outcomes.
• Show valuable insights into scaling up these processes, addressing challenges such as seed supply for GMP setting, and ensuring safety and environmental considerations.
• Apply acquired knowledge and practical skills to navigate the complexities of seeded crystallization, enabling you to contribute to efficient and robust large-scale crystallization processes in diverse industrial settings.